When asked about whether the U.S. has a plan on how to fill the power vacuum left by the death of the nation's supreme leader, Rubio reiterated that their goal was to destroy Iran's short-range ballistic missile capability and eliminate the threat posed by its navy.

"We hope that the Iranian people can overthrow this government," Rubio said. "We would love for that to be possible."

When asked directly if the U.S. will play any role in helping Iran with its government, Rubio shrugged and said, "we might."