For a lot of things, my group will keep it level... But Persuasion is a free for all. And it goes both ways.

PC 1: "My Femme Fatal attempts to seduce the Orc guard."

nat 1

DM: "You attempt to talk up the muscular green bastard, who doesn't seem all that impressed. You pester him a few minutes before he snarls, pulls up his sleeve to show you the rainbow flag tattoo on his arm and says 'Fuck off, lady. I'm gay!'"

PC 2: "...Can my Engineer try to seduce the guard?"