I like BTRFS's checksumming abilities and compression the most. BTRFS will keep track of every block of data's checksum, and when you run a scrub it will detect bitrot. If you want to heal the bitrot you'll need to run e.g. RAID1. RAID5/6 are not stable so don't use those. ZSTD:1 compression is basically free storage with no downside, and can massively speed up file operations if you're using spinning rust.

Personally I run BTRFS on any disk that only needs a single drive, like OS disk or games drive. My NAS runs a ZFS array for any mass storage, which includes basically the same feature set as BTRFS, except RAID actually works and everything is a tiny bit better. A ZFS NAS isn't very good unless you pump a decent amount of money into it to get it going, so if you're on a tight budget I'd recommend MergerFS+SnapRAID backed by BTRFS disks, which is very similar to Unraid in terms of storage paradigm except free.