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Cells at Overwork - Last Place Comics
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I think it's mostly the amount eaten.
When prepared from basic ingredients pizza and pasta are the exact same ingredients : flour, salt, tomatoes, cheese and some extra toppings.
Except that when I'm making pizza at home I know I have to double the amount of flour compared to pasta.
I don't know why but we are just eating so much more when it's pizza rather than pastas or another meal.