The ISS is a multi decades-old vehicle that is already operating past it's original exploration date. Let's see what we can do when we build using new construction methods and design philosophies with technology from the 21st century, far larger fairing capacities and also with 20 20 hindsight.

Also the moon. We're gonna build a base on the moon. Which does have some gravity so some of those issues will go away or otherwise be mitigated (there's enough gravity to make things fall down so that's toilets and showers sorted).