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Encephalitis lethargica - Wikipedia
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Awakenings, by Oliver Sacks, is a book of case studies concerning the L-Dopa treatments of patients of the epidemic; it is a profoundly moving book. Dramatized into a film starring Robin Williams and Robert De Niro (and, incidentally, the single most emotionally manipulative, heart-wrenching film I've ever seen, by a fair margin--medical horror is hard to beat). Up there with brain-eating amoebas and rabies for me when it comes to terrifying afflictions.
I once, years ago, began reading his “The Man Who Mistook His Wife for a Hat” and didn’t make it far!
Very often, the reality of our own fragility and fragmentation is more dreadful and creepy than most horror.
Maybe it’s time to pick it up again.