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How likely is this to work? KVM/VFIO Single GPU Passthrough
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I used to use VFIO several years ago, but these days every game I want to play/ have played recently have all just worked out of the box with Proton. VFIO was always fragile, but it worked great when it did. It has the same problems Proton has with anti-cheat, since its still a VM. So your milage varies depending on the games you want to run.
That was my experience as well: ran VFIO for a couple years but Proton got good enough that the trouble wasn't worth it.