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Malignance Runs Rampant in the First Season of Diablo IV
(news.blizzard.com)
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You can start a seasonal character without completing any campaign. What you can't access is the seasonal content. This starts after you complete the campaign - so you won't see malignant creatures or the quest line or gems or whatever until you've completed the campaign.
Which is why it boggles my mind they can't enable it for the Eternal realm. It is practically already set up to worl that way!