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The WHO is about to declare aspartame can cause cancer
(www.vox.com)
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this post was submitted on 08 Jul 2023
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There is a lot of public misunderstanding of the rodent studies that linked aspartame to cancer, which are very flawed and essentially come from a single Italian research group.
There is still no definitive link to cancer risk in humans so I would continue to be skeptical. The maximum recommended safe exposure for aspartame is the equivalent of 12 cans of coke, and the strong effects from the rodent study were using exposure amounts equivalent to 5 times that amount, or 60 cans daily, every day of their life after day 12 of fetal life (i.e. before birth).
Almost anything can cause long-term health risks and toxicity at such massive exposure levels.
https://www.cancer.org/cancer/risk-prevention/chemicals/aspartame.html
Link to the free Pubmed link to one of the original source studies from 2008 so you can see their methodology and the absurdly massive exposure amounts needed to ovserve these effects:
https://pubmed.ncbi.nlm.nih.gov/17805418/
I disagree with the 'massive' exposure 'needed' to observe these effects exaggeration. First, the point of the study was to show it can be carcinogenic, not to parse at exactly what level in humans. Second, effects are seen at the 400ppm level which equates to 20mg/kg. This is 1600mg/day or 8 cans of Diet Coke (@200mg/can) for an 80kg male. That is NOT an impossible level of daily consumption for many.
I suspect further research was done to confirm your linked studies and refine exactly at what minimum levels of daily consumption elicit carcinogenic effects. That will likely be in the full report once released. Until then, you sound like you don't want it to be true, rather than an impartial evaluator of the research.
Almost anything can be carcinogenic with a high enough exposure. You can pump a rat full of water until it dies and declare that water kills people. But, that doesn't prove anything or serve a point.
In rats! You can't just multiple a rat study by body weight and expect it to always correlate. That's why studies are done in larger animals, and sometimes the concept just dies there.
A single study is a statistic. Until they duplicate the results multiple times, and upgrade to monkeys, pigs, or (in a safe way) humans, this is all just noise.
I'm going to agree with Burstar here - if you're setting out to prove that something is possible, you're going to give it the best chance you can. Once you know its possible (whether its something like using an arduino to simulate an old price of hardware, or if a compound can cause cancer), you go and refine it down.