Specifically to the isolation, lately I've been volunteering twice a week. Not a "cure", but it's been an improvement for sure.

Depression is another beast entirely, though. I like to think I'm "out" of it now, but it took me a long time to get here.

One thing my therapist suggested was to find your values and try to work toward those. So for me, I've found that I care a lot about Education and Community, so I started volunteering teaching English to refugees.

I'm generally nihilistic, but when I'm volunteering it makes me feel better to know I'm making their lives better. Gives me a sense of purpose where it was always lacking before.

I hope you're able to find something that works for you. Just remember that things can and will get better, even though it can be nearly impossible to believe that when you're "in it" so to speak. Just keep going, and only do as much as you're able.