There's many regional differences in American English.

First, pronunciation is always changing, and changes tend to happen regionally.

For example, there's the Mary-merry-marry merger. A bit over half of American speakers pronounce all three of those words identically, as mɛri. About 17% of Americans have a full three-way contrast. In NYC, for example, they'd say meɹi, mæɹi, and mɛɹi. And other people merged two of the three.

The pen-pin merger is a famous feature of southern American dialects.

Some words have regional pronunciations - crayon can have one or two syllables, for example.

And then there's regional words, like pop vs soda, bucket vs pail, firefly vs lightning bug, you vs y'all vs yinz vs youse vs you lot vs you all vs you guys etc.

By asking about all of those sorts of things, you can figure out where someone's from.