I've been running ITX gaming builds for years, they work great and I don't use expansion ports anyways.
My advice would be choose the case you want first. Bigger ITX cases will take standard components easily (with some limits on GPU length), but if you want Very Small and Mighty (e.g. DanCase, Fractal Design Terra), component choice becomes very important. You'll need to consider cpu, gpu, and cooling clearances.
It's like PC building on moderately hard mode, it's a little more difficult but the results are worth it!
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I've been running ITX gaming builds for years, they work great and I don't use expansion ports anyways.
My advice would be choose the case you want first. Bigger ITX cases will take standard components easily (with some limits on GPU length), but if you want Very Small and Mighty (e.g. DanCase, Fractal Design Terra), component choice becomes very important. You'll need to consider cpu, gpu, and cooling clearances.
It's like PC building on moderately hard mode, it's a little more difficult but the results are worth it!
I was drooling over that Terra only last week but ended up going North. Beautiful cases!