With Lutris, I got stuck on an error about architecture. I tried changing WINEARCH to WIN32, but it didn't work. Tried making a new systemwide default prefix in win32, didn't work. Went down a bit of a rabbit hole on Google but I was not able to get the game to even install, let alone run.

With proton, games install and typically run, but not without issues. For example, when Return to Monkey Island launched, it was Windows-only, so I tried it in Proton. It worked for a day, then mouse input just stopped working entirely. Half an hour of trouleshooting later I decided it would be easier to just boot into Windows. That's the general experience I've had with Proton, even for Steam Deck certified games. And then sometimes games run but with unacceptable performance, like Stray.

Until recently I was stuck on the 510 drivers because the newer ones broke CUDA in the Ubuntu repositories. That was recently updated to I think 525, but I haven't tried any games since updating. But I also had similar problems on Suse with drivers from Nvidia, and the old Ubuntu LTS (18.04 was it?).

If Lutris is going to be so finicky about Wine versions and prefixes, I wish it would just bundle its own instead of using the system wine. I use Wine for other things and can't easily nuke my whole config.

I've basically given up on playing non-native games on Linux. It seems like this is a "me" problem but I can't imagine what's so unique about my Steam install. I try to keep as close to stock Ubuntu LTS as possible precisely to avoid these issues, but here I am.