I always saw the "real food is better" attitude exists as either a hipster thing or simply because recipe they prefer just doesnt exist in the database. In TNG we see people from the past try repilcated food and absolutely love it.

So (hipsters aside) a home cook would also be more likely to have some minor variance in their meal while the replicated version would be identical on each plate every single time. I imagine the heterogeneity may be part of the appeal of human prepared meals. The replicator also may have grandma's beloved secret recipe, but not your grandma's secret recipe.