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The Nix daemon itself still uses root at build/install time for now. NixOS doesn't have any built-in sandboxing for running applications à la Docker, though it does have AppArmor support. But then, NixOS doesn't generally have applications run as root (containerized or otherwise), unlike Docker.
You don't need to build/install with root, you can do home-manager
And for isolation there's one good module, I forgot its name
And if just easier but less reproducible, you can do the containers, but with nixos' podman, and this is of course builtin