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is Wine with -O3 and -march=native a placebo?
(lemmygrad.ml)
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IMO there's no point in optimising without being able to measure the results.
A profiler should be able to tell you how much time is spent running the code you're attempting to optimise. It might turn out that the wine runtime code is not a significant factor in performance.
I bet Phoronix has benchmarks of this
i searched phoronix and found nothing, they did other programs whenever a new gcc version launched, they compiled a lot of benchmarks with different flags and measure compile time and program performance, some programs gained a noticeable with -O3 -march=native