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GOOD games with female protagonists?
(beehaw.org)
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Assassin's Creed Odyssey female lead is canon, although you have the choice to play the male as well.
Same for Valhalla. Which interestingly canonically has a female player character for the vast majority of the game (the "real world"), but a male lead for the shorter Norse mythology parts of the game. There's a lore reason for it. Though the game does let you actually choose whichever gender you want for either part (but it does recommend the canonical choices). The modern day character is also a woman and has been since Origins.
For an older style AC game, AC Syndicate has you play as opposite gender twins in Victorian London. It's one of my favourite AC games. You do have to play as both twins for some length of the game, but a significant amount of the game lets you choose which to play as (and Evie is more fun to play IMO).