I think a good way to handle this – as well as the wildly unpopular accessibility functions the post is about – would be to have it configurable and simply ask about it during initial user setup (aka OOBE).

That way people who didn't need it can turn it off and won't stumble over it after accidentally pressing the Windows key or holding down Shift a bit too long. People who need it can have it enabled right from the get-go without having to trigger some dialog first. Everyone's happy and having one extra step during initial setup isn't that much of a hassle.

Bonus points if Windows had configurable global hotkeys and I could make the Windows key do whatever I want. But the OOBE thing would be a good solution already.