I remove the GPU because it's so heavy and will damage the slot. Then just place it behind the passenger seat in the footwell surrounded by soft stuff (pillows, blankets, towels, etc) and roll the seat back so it's snug and firmly locked in. All you're looking to do is prevent shock. Movement is totally fine, but hitting a big pothole with nothing to absorb isn't ideal.

Safely transporting your panels requires more care. Don't want any pressure or objects to get on the displays. One object slightly moving can press a bezel or rest on the panel 10 miles in and just do damage over time for the next 690.

Edit: Shit, I prob should've mentioned how to transport panels. With as much clear room as possible. Back down, face up, no point covering the screens it'll just put a very false sense of security in. I will put them in the passenger footwell and on the passenger seat. If I have "plenty of room" to fit another box, I do not. They need that room. They are expensive, they are fragile, they are critical. They're like massive exposed motherboards that cost a lot more qnd don't have a PC case protecting them.