Road-trip, road-trip!

Going to louisville is a fun quest, it's a long way from muldraugh! I know muldraugh pretty well, got a character that lived for a bunch of months and never went too far from that part of the map.

I went to louisville a few times but never settled there, it's much more tense. If you're not careful/experienced you get swarmed very quickly, and once you start being chased there are so many zombos everywhere you're not likely to find a safe spot before being exhausted. You need strats, often a way of making a noise distraction, etc. Or a good team that knows how to fight, or a shit-ton of ammo but even then the sheer amount of zombies in a place like louisville makes it hard to ever really "clear".

Zombies respawn over time in any cell that hasn't been visited by a player in a little while, depending on your sandbox settings that can be a few in-game hours, days, weeks, etc. It's hard to ever be entirely safe, even very well built safe-houses or areas will have zombies appearing in them if they don't have players in them for too long. The game's better than it used to at this process and you have less instances of zombies weirdly spawning inside places where they should not have been able to get in, but afaik it still happens.

Anyway, going to louisville is a pretty fun adventure and it can be quite difficult. Even with good gear and a good car, you get stuck in the road in places with a lot of car jams, or at the military/quarantine checkpoint around louisville.