Eh, it's not too bad:

1. Settings
2. System
3. Multiple Users -> Allow
4. Add User

Then to switch, there will be a new icon next to the Settings icon when you swipe down. Tap that and select the profile you want.

I use GrapheneOS, which ships w/o Google Play by default (installation process is a little trickier, but still easy), but most phones won't have an option to uninstall Google Play since it's a default system app. But if have managed to install GrapheneOS, setting up a profile to quarantine your Google Play apps is pretty easy.