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Anon casts a healing spell
(lemy.lol)
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Even with regenerate, what exactly are you regenerating? If the necessary neural pathways for the legs to work never developed in the first place, they couldn't be "regenerated". If this was your goal I think you might need to true polymorph a guy into "the same guy but his legs work"
You couldn't "restore" something to a state it's never been in. Cutting off the legs and then casting regenerate would "regenerate" the lost pair of paralyzed legs.
"Your nerves are forged anew, and your legs are as strong as a marathon runner's. Unfortunately you never learned to walk, much less run. Good luck."
I don't think logic applies to healing magic in DnD lol.
Is logic not the role of the DM?
“You touch a creature and stimulate its natural healing ability.”
If stem cells could solve the issue, it’s possible. Turn it into a surgery, high DC medicine check, or an insane arcana check and a DM would probably let it play.
Simulacra and Clone, or Greater Restoration should be able to achieve the desired effect, provided a competent heal check.