Yes. If you know the material’s molecular composition, you can tune a series of lasers to break those bonds with minimal energy input.

You don’t even need the explicit makeup of the material. You can just do a quick calibrating scan consisting of a rainbow sweep of every frequency, while watching to see the scattering pattern of the photons.

Assuming that your laser tuning system makes different tones when it’s producing different wavelengths of light, your weapon’s appearance while firing would be like:

• It makes a sound like VWEEEP and plays a shifting rainbow pattern across the object to be disrupted
• Once calibration is complete, it makes a loud BWAAAAAH sound as the object turns to vapor/powder

The calibration is only like one second. These properties conveniently make it awesome to include in a cinematic depiction such as a sci fi movie.