Adding my "Me too" to Vorta/Borg. I use it with Borgbase, which I like because it's legitimately cheap and they support Borg development. As well, you can set Borg backups with Borgbase to "append only," which prevents ransomware or other unexpected "whoopsies" from wiping out your backup history.

I backup most of my computer every hour, but have pruning rules that make sure things don't get too out of hand. I have a second backup that backs everything up to my NAS (using Vorta, again). This is helpful for things like my downloads folder, virtual machines, or STEAM library - things I wouldn't want to backup over the network, but on occasion I do find myself going "whoops, I wanted that."

I also have Vorta working on my Mom's Macbook, then have Borgbase send me an email when there isn't any activity for longer than a couple of days. Once I got automatic pruning working right I never had to touch this again.