Swapping my own group to PF2e and we've all played other systems (lancer, sw saga, vtm, cyberpunk, kids on bikes, etc). I do think if a meme says something different than DnD (using it as a generic term for TTRPG) you'll get more people commenting on the system rather than relating to the meme (like if this said Traveler there'd be more comments about never played Traveler or if it said PF2e comments would be more about the system war).