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What's science fiction without the machines?
(leminal.space)
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If I'm understanding this correctly, you're looking for fiction that focuses on framing more of cultural and societal shifts than technological changes?
What you're looking for is difficult to find in the framing of Science Fiction because its very framing invokes technological advancement - technology is the application of science, and machinery is the result of technological innovation. Science fiction is, at its core, about how discoveries in science may change the world.
Nonetheless, you may want to look into the sub-genre referred to as "social science fiction". Although it's not going to be devoid of advanced technology, the focus will be more on the social and societal impacts thereof, than the machinery itself.
Machinery's certainly a result of technological innovation, but not the only result. Different materials, even altogether different forms of organisms are also results of technological innovation. OP's left it rather open, so it may be that they also mean these different applications of science.