BoI is still one of the best feeling roguelites ever.

But it also very much suffers from the design philosophies of the 2010s. Because you are going to do one of:

1. Spend a LOT of brainpower memorizing all the upgrades and their synergies
2. Have a wiki open off to the side and reference it every few rooms
3. Just YOLO and feel like the entire game is RNG

Because there are way too many upgrades that end up being downgrades that can just kill a run completely unless you plan for them. And there is no good way to understand that in game.