it’s getting more prevalent as more stuff (especially servers) run on Linux [...] Linux’s days of living in “security through obscurity” are over"
Servers are primarily running Linux for decades. So any security through obscurity would be gone for as long, if it even existed ever...
though I’ll admit to not having tested that sort of thing with Wine/Proton installed
The more primitive the better the chances. And there are some really primitive cases of ransonware perfectly happy with running through Wine and encrypting your files. So limiting Wine's file access (or better running it as a separate unpriviledged user with no access to anything but your games) is always a good idea.
We are talking about 40k here, so dying will probably be the nice outcome you hope for...