Currently giving it a try on a small API+async task project.
I think the hardest thing for me has been discovering which dependencies are (can be) injected and through what magic string. But, it's also easy to step through the source to find answers.
After many years of DIYing validation with Django, then attrs+flask, and then getting a lot of that work for free with pydantic+fastapi, msgspec+litestar feels like the natural evolution into a mature pattern.
The sqlalchemy models are first-class citizens, the service and repository classes just work (especially well if you use their advanced alchemy wrapper).
And the devs are very responsive (fixed a tiny bug I found in a weird corner with tests in a matter of hours).
I'm gushing a bit. So I'll just end it by saying I agree with the author: it's worth a look.