The strike began on May 16, 1934. The strike was remarkably effective, shutting down most commercial transport in the city with the exception of certain farmers, who were allowed to bring their produce into town, but delivering directly to grocers, rather than to the market area, which the union had shut down.

The market was to be the scene of the fiercest fighting during the earliest part of the strike. On Saturday, May 19, 1934, Minneapolis Police and private guards beat a number of strikers trying to prevent strikebreakers from unloading a truck in that area and waylaid several strikers who had responded to a report that scab drivers were unloading newsprint at the two major dailies' (newspapers) loading docks. Police followed injured strikers to the strikers headquarters. The strikers refused to let the police into the headquarters, leading to more violence between police and strikers.

Fighting intensified the following Monday, May 21, when the police, augmented by several hundred newly deputized members of the Citizens Alliance, an employer organization, attempted to open up the market for trucking. Fighting began when a loaded truck began leaving a loading dock. The battle became a general melee when hundreds of pickets armed with clubs of all sorts rushed to the area to support the picketers; when the police drew their guns as if to shoot, the union sent a truck loaded with picketers into the mass of police and deputies in order to make it impossible for them to fire without shooting each other.