AutoHotKey AHK for short. Allows automation of nearly anything in Windows, and is better than most alternatives. The downside is it's VBScript, which I believe is going he way of the dodo, and it has quite a few gotchyas.
However, on day one you can start assigning keys and combos to do common tasks.
Don't like Caps Lock? Reassign it to open Chrome. Hate that you can't lock the screen with your left hand? Make Win+S a command that locks the screen.
It's free, has a huge community, and is truly amazing.