There really are little to no economic concessions Cuba can make, given the status of the blockade on the country. If the “deal” was just to let Trump build his own hotels on the island or something, Cuba might even accept that. Given this and who is in Trump’s cabinet, I think it’s reasonable to assume the only “deal” on the table is to accept being governed as US colony with Rubio as the viceroy.
As brutal as cutting off oil from Venezuela will be, the Cuban people got through the Special Period, I think they will survive Trump.