Blender for the texture painting

Material Maker for turning those textures into game engine ready materials. It's also capable generating textures using noise and other patterns. Examples

Armorpaint might be what you are looking for. Blender texture painting is nice, but Armorpaint is much closer to the substance painter experience.

Edit: For example, with Blender texture painting, unless you're familiar with nodes, you would usually only set up one texture at a time.

Armorpaint also uses nodes, but it also uses a layer system just like substance painter. You can then modify the texture using nodes if you want to.

Never tried these but: https://armorpaint.org/ // https://github.com/armory3d/armortools

edit: Seems like Blender is capable of this too: https://www.youtube.com/watch?v=AnRQhH3fEDY