I self hosted a Lemmy instance for a little while, but I stopped over concerns of malicious actors posting CSAM which would then get federated over to my server. I don't have the appetite to deal with that, and I'm glad I shut it down because just a few weeks later there was a big instance of it happening all over Lemmy, and I'm sure I would have had to deal with cleaning it up on my server too. Just something to keep in mind.
Otherwise though, the setup process isn't too complex.