Life evolves in a certain environment, and usually anything that changes that environment will be bad. And some organisms adapt to that bad, and some don't.

An example of this is stuff like highly processed foods, coffee, cigarettes, alcohol, drugs, women in the workforce, and effects of fetal health. I am in favor of women's rights, but female stress and alcohol use and cigarette usage have all been found to affect prenatal health, and women in the workforce during pregnancy may be correlated with higher female stress. (I am in favor of women in science and working, that is not an anti-woman comment.)

So the human body is always signaling to other cells and neighboring cells and if there's plastic blocking the signaling, it's going to effect how cells grow and die and likely their epigenetic expression. The question is how much? If the microplastics are damaging cells, and they likely do but knowledge to be sure, then there's resulting healing processes that may increase inflammation, and inflammation has wide-ranging effects on organic systems.

I can't fathom that these microplastic don't impact prenatal health. Babies in utero are more impacted by smaller things because it changes the growth patterns.

It also seems very likely to me that having things like this, which could alter epigenetics and brain structure growth, would possibly result in more varied phenotypes (ie, more autism, more transgender people, etc) and more miscarriages. I say this as someone who is pro-LGBT, but a lot of these microplastics act as endocrine disruptors.

When you see Elon Musk doing so much Ketamine that he's starting to, according to some, lose it, and he's possibly using Ketamine for depression, it is likely because of how environmentally fucked the planet is. His whole angle is to get the fuck off this planet and try again somewhere else and it may or may not work.

This planet is environmentally fucked, and environmental problems show the core problem with Democracy: when you have scientific idiots choosing which psychopath to govern, it doesn't usually result in ecological harmony. Then all the communist governments are just trying to compete with the capitalist governments, fatally chugging along. The Scandanavian countries, with their death metal and embrace of nihilism, are filled with people who accept that we may all be doomed, although some of them are trying. Then you have pockets of liberals all over who are keyboard warriors while the real activists are few and far between. And it may not even matter if there is activism. It's almost certainly too late and we're all going to die. Try to look surprised when it happens.

It's likely the microplastics are making human stupidity increase, thereby leading people to ignore environmental logic, thereby leading to more microplastics, thereby increasing human stupidity, etc.