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Learning Magic - an 1100 Webcomic
(ttrpg.network)
I'm not sure it qualifies as a meme, exactly, but I did the art, and not the words. (Original text from @MicroSFF on Twitter)
In truth, I use whatever is handy - from paper and pencil to whatever app(s) I have access to.
That said, I’ve just started playing around with Affinity Designer 2 - which I suspect would be a lot like working in Inkscape (since they’re both vector based).