Misskey's a vibrant colorful very interactive experience
Bluesky's a very good Twitter alternative, at least for now, although it's owned by a VC-funded startup so we'll see how long that lasts
Mastodon (and even moreso forks like Glitch and Hometown) are good if you want a small-to-medium size community along with the ability to be part of broader conversations. It can be a decent Twitter alternative for some people (especially white techies) but Bluesky's a lot more usable, easy to get started on, and diverse.
Yes there several english-speaking instances running Misskey or a fork. Here's the list for Sharkey - https://fedidb.org/software/sharkey