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Scientists aiming to bring back woolly mammoth create woolly mice
(www.theguardian.com)
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And that’s basically it!
Not really, we humans killed most big land animals that we found as we expanded our territory, back when we were hunters. This happened in big "islands" like Australia and Madagascar, as well as all the small islands. There, large animals had lived in equilibrium for centuries, and their extinction matches some short time after humans arrived. An exception are the galapago islands, as they were discovered in the 19th century.
Besides the fact that the hunting hypothesis is that; a hypothesis, there's a lot of other factors as to why it isn't a good idea. Mainly, ohh idk... The fact that they have had no place in nature in over tens of thousands of years? Even if we managed to create an artificial habitat and role in an ecosystem for them, they would be very vulnerable due to megafauna's increased minimum land requirements because of their size and in danger constantly due to climate change.