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GUI Programming Recommendations
(lemm.ee)
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Linux is a family of open source Unix-like operating systems based on the Linux kernel, an operating system kernel first released on September 17, 1991 by Linus Torvalds. Linux is typically packaged in a Linux distribution (or distro for short).
Distributions include the Linux kernel and supporting system software and libraries, many of which are provided by the GNU Project. Many Linux distributions use the word "Linux" in their name, but the Free Software Foundation uses the name GNU/Linux to emphasize the importance of GNU software, causing some controversy.
Community icon by Alpár-Etele Méder, licensed under CC BY 3.0
You could get started with Qt, specifically the legacy widgets. There are bindings for Python available (pyside or pyqt) if you don't want to learn C++ or another language right away. You can also port your GUI definitions to other languages at a later date.