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Every. Single. Game. Ever.
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The marker wanted to stay off of Aegis VII, actually. Their entire goal (as we learn in 3) is to spread the Necro infection and eventually make a Brother Moon. It's likely the marker kept attacking Isaac in an attempt to stop him from putting it back on the planet that was about to fall apart. Isaac's mental infection isn't hardcore until DS2, either, so he's not being manipulated very hard yet
Dead Space gets fucking complicated if you read the extended lore in all the games holy shit I sound insane
Mercer is the guy making the invincible Necro. In the remake he kills himself willingly, in the original he's "betrayed" by the marker. The guy helping you is June, poor bastard