And it doesn't fucking work. Like, straight up, Spravato doesn't do anything to improve symptoms of treatment-resistant depression.

While a ketamine infusion given in a controlled environment and combined with talk therapy (like DBT) can help manage treatment resistant depression, this isn't that.

Even the clinical trials for the drug didn't indicate a statistically significant reduction in MADRS scores versus placebo, and seemingly the only thing it did was unblind the study. The fact that this drug got approved is genuinely shocking to me.