Yes, they are

Minor:

Goodsprings: It's a small town, they don't matter in the grand scheme of things.

Primm: same as above

Powder Gangers: Just a criminal organization. Beyond the Vault 19 ones (which seek revenge on the NCR, but don't really have any goals), they only seek to maintain their hold over the Western Mojave and it's a matter of time before a pissed off larger group wiped them out.

Brotherhood of Steel: A successor organization of the United States Army, focused on hoarding advanced technology out of a belief they're inherently better than the society left standing. Isolationist, militaristic and very stagnant. There's probably not a single good ending for the Mojave where they're left existing.

Novac: Another case of small town, small influence. Except that they're also near the front, so would be wiped out easily by the Legion.

Bright Brotherhood: A generic cult, which doesn't have much appeal outside of the ghoul population.

Great Khans: A communal-living nomadic society, haunted by its roots as a criminal gang and being a victim of NCR war crimes. The ending where they leave the Mojave is interesting, because they're said to work together explicitly with the Followers of the Apocalypse, but we're likely never going to see what this would lead to because we're not going to see a non-Bethesda non-mobile-shovelware Fallout game again, and especially not one set in Wyoming.

Boomers: A somewhat brainwormed isolationist community. Their enthusiastic usage of heavy artillery and the bomber from lake Mead makes them unpredictable.

Followers of the Apocalypse: A mostly humanitarian organization influenced by some left wing thought, such as community organizing and opposition to the profit motive. However, they're a big tent organization with very decentralized structures so you have their members acting in diverse political ways. The man later known as Caesar and Joshua Graham were both members, and so is for example Bert Gunnarsson (from the Aerotech Refugee Camp) who ignored the FotA severing ties with the NCR Government to work with them anyway, or Tom Anderson who instead sabotaged the local NCR by stealing water supplies, and so is also Emily Ortal (who helped out Benny). Others, like Julie Farkas, meanwhile are more passive.

The Kings are a local gang, if more benevolent than the average.

The Omertas are scum.

The Chairmen are pretty passive political actors, except for the man, the legend, Benny. He's a bozo and a dollar store Indipendent!Courier, but I love him.

The White Gloves are the Bourgeois of the future.

The Jacobstown mutants are a small community that wants to be left alone.

Major:

The NCR is a modern liberal state. That is, corrupt to the core, driven by bourgeois interests, led by Bozos, sustained by imperialism and on the verge of environmental collapse.

The Legion is "first as tragedy, then as farce" - Mussolini Edition.

Mr. House is a less clownish Elon Musk. He thinks he knows how to solve the problems of the world. So while he's dreaming of sending people to space colonies within a century, he's perfectly happy that his "lol let's rebuild the Strip" displaced out lots of people into Freeside, turning it into a crime-filled slum.

Indipendent Vegas is left up to the players' Interpretation + what happens to the other factions, really.