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Hot take: Strongest creatures in the setting shouldn't just be clowned by PCs with no resistance.
(ttrpg.network)
Inspired by frustrating conversation I had. For those curious, that was the statblock of Caine, father of the vampires.
Also WoD:
Player: I’m a mage I’m literally changing reality, I will cure that vampire.
System: vampirism is a curse from God, do you really think you can roll more successes than God?
We used to talk about how to cure Vampires in Mage (awakening, 2e).
The easiest is probably time magic. With Time4, rules as written you can rewrite their history so they never became a vampire. It persists until the spell elapses, but you could make that last a year without too much trouble (assuming time4, gnosis3, a rote skill of 4).
With Time5, the "fuck you" level of Mage, you can use the Unmaking practice and prevent them from being embraced, though that's big hubris and risks butterfly effects at the GM's discretion.
Other approaches I'm less sure about. You could probably do something with Life5 (make a new body), 5 or so points of Death or Spirit to get a new soul (fun fact: in awakening, souls are fungible), and Mind5 to put their mind in the new body. Kind of a ship of Theseus situation.
In oWoD meanwhile there is an entire book with ideas how Mages could fix a vampire and what would be the consequences.