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Growing Stinging Nettle
(beehaw.org)
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They don't help with allergies, unfortunately (that's just pseudoscience bunk), other than in the general ways that nutrients can be helpful to being healthy - but the claims about histamine are magical thinking.
Nettles are a perennial, you don't need to let them go to seed - it's only disadvantageous to do so, since as they flower they form cystoliths in their leaves, which will hurt your kidneys (you can still harvest them but you have to ferment them to make them safe to eat at that point).
Nettles are pretty tasty, more strongly flavored than spinach, though.