I'm using Bazzite on hardware that is, notoriously Linux unfriendly (nvidia GPU, partitioned SSD...)

And the only major issue I had was completely self-inflicted: I tried turning on Frame Gen in Cyberpunk and it made it not happy. The game was unplayable.

The minor issue I had (that was actually OS related) was some color accuracy issues - everything looked washed out on a default install, some googling got me to a small piece of software that I set to launch on login that fixed it, allowing me to set my color saturation how I want.

Aside from that, it's been pretty straightforward. I don't play many multiplayer games, and the one I do (OSRS) is pretty well-supported. The client everyone uses runs well and I was able to install the Jagex Launcher just fine, even if it is unsupported it works fine.

Bazzite desktop has been the best desktop Linux experience I've ever had and I'll probably stick with it going forward.