Sure. The following are the bits that I'm pretty sure are universal. The rest -- mostly configuring my audio interface -- is IMO fairly specific to my system and can be found in my dotfiles.

• Limits for Pipewire:

  # /etc/security/limits.d/25-pw-rlimits.conf
  @pipewire   - rtprio  95
  @pipewire   - nice    -19
  @pipewire   - memlock 4194304
  

• Add the realtime group and grant it access to /dev/cpu_dma_latency so Ardour can prevent the system from going into idle:

  # /etc/udev/rules.d/40-realtime-privileges.rules
  KERNEL=="cpu_dma_latency", GROUP="realtime"
  

• Add threadirqs and preempt=full to the kernel commandline
• Disable VM swap readahead since Kinoite uses ZRAM anyways:

  # /etc/sysctl.d/50-audio.conf
  vm.page-cluster = 0
  

• Set IO scheduler to None for SSDs and NVMe:

  # /etc/udev/rules.d/60-block-scheduler.rules
  ACTION=="add|change", SUBSYSTEM=="block", ATTR{queue/rotational}=="0", KERNEL=="nvme?n?", ATTR{queue/scheduler}="none"
  ACTION=="add|change", SUBSYSTEM=="block", ATTR{queue/rotational}=="0", KERNEL=="sd?", ATTR{queue/scheduler}="none"
  

I'm not using a preempt kernel or anything like that; I've only gotten into audio when Pipewire had already hit the scene and I've found it to be good enough with these settings.