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this post was submitted on 20 Feb 2026
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Asklemmy
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It depends really what you want out of it. Also, yes your tolerance increases pretty rapidly. I recently took a 250mg dose and didn't feel it. An hour later I took another, and ended up with some slight euphoria and visual effects. You can always take more, but you can never go back and take less!
Looking to have an uplifted mood, motivation, less anxiety, not a psychedelic trip.
like others have said, it's up to your tolerance levels and your body's ability to metabolize it. i've had good luck w moderate-to-high doses, once a month at the most, for the last decade or so.
I understand. I can't do tripping anymore myself. I do think a lot of microdosing is basically placebo. As everyone is different, you will kind of have to experiment with what works for you (which you're already doing!). That said, I'm really not surprised that 100mg didn't do anything for you.
I did 200mg today, still nothing. Tomorrow I'll decide whether I take 300 or 400.