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this post was submitted on 20 Apr 2026
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Chapotraphouse
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For anyone reading, it is the acidity in your stomach from something like orange juice that alters the uptake of amphetamines. Adderall, for example, is a weak base which becomes more ionized in a highly acidic environment and cannot pass through membranes as well.
My question is does Vitamin C only have its effect on the drug during uptake and not after several hours of the drug having passed through your body?
Only during uptake. Once it’s in your bloodstream, the acidity of your stomach and small intestine will no longer play a factor.
I would say uptake happens over 2 hours at most, especially if you’ve just eaten a large meal
No no no and no.
Vitamin C doesn't do shit.
Citric acid, when in contact with the physical pill, will break it down.
Once there is no more pill, cause its been metabolized, the citric acid in your stomach doesn't affect it any more.
Once you've metabolized it, you've metabolized it.
This is only half right, vitamin C does increase the acidity of your stomach. And it is not the physical breakdown of the pill, but how the increased hydrogen ions (H+) bind with the amphetamine molecules and prevent them from crossing your lipophilic GI membranes.
Dope. I'm super not into chemistry, but I saw enough misconception to try and clean up before someone started trying to offset drugs with drugs.
So, lemme poke this a bit...
First, its basically any acid. But stronger means higher impact. Vitamin C is not the important chemical, but it does increase the effect cause its stronger than stomach acid?
Lipophilic... Fat loving... Okay so in the stomach the acid works to neutralize the adderol, but higher acidity means more ionization which makes it harder to absorb through your stomach or intestinal lining?
Are those assumptoons correct?
Still thiygh, once your body has metabolized the adderol into your blood stream, you gotta deal with it being in your blood stream.
Yeah it’s any acid, and I think the acidity actually comes more into play once the drug and the acid enter your small intestine as it’s hard to beat your own stomach acid.
Yeah that second part is right, I don’t really recall the mechanics of it well enough to explain but this gives a pretty good breakdown: https://www.merckmanuals.com/professional/clinical-pharmacology/pharmacokinetics/drug-absorption