I love the setting of Brancalonia. I love the humor, I love the folklore, and I am currently learning Italian in evening classes to boot, so this is basically a perfect mix.
But I do not love that the authors picked D&D 5E as the rule system for this setting. Don't get me wrong, I find D&D 5E perfectly acceptable for heroic fantasy campaigns (and, in fact, I am running such a campaign right now). And I can understand this choice from a business perspective - it makes a lot of sense to tie your setting to the most popular RPG system out there.
However, Brancalonia PCs are not supposed to be great heroes, but fairly unimpressive never-do-wells. The rules deal with this by capping character level at 6, but I feel that this leaves the PCs with too little room to grow and removes much of the proper D&D experience. I'd rather use a rule system that was intended for weaker protagonists, rather than trying to distort D&D into something that is not.
So, what alternate system would you use for Brancalonia?
Check out legend in the mist, new system that just dropped recently. Seems like this would mesh well with the rustic fantasy motif it has going on and its also easily adaptable