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this post was submitted on 11 Sep 2023
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While you didn't get the data you were looking for, at least in many of those cases you mentioned you did identify a flaw or failure and learned how to design an experiment that does.
I wouldn't consider those mice as dieing without teaching you something. It might be a failed experiment, but you learned something.
I may be misreading them but it sounds like they're describing avoidable problems.
Like when we were doing "oral" vaccinations with a oral gavage needle (ball tip) and going through the mouth and dosing in the stomach. We had a vial of 70% alcohol to clean the tip. Accidentally drew the alcohol up instead of the vaccine. By the time we finished the cage (6 mice, I think) the first one fell over.